.signatera-page {
  clear: both;
  width: 100%;
  color: #294852;
  background-color: #fff;
}

.signatera-page *,
.signatera-page *::before,
.signatera-page *::after {
  box-sizing: border-box;
}

.signatera-page section {
  clear: both;
  width: 100%;
}

.signatera-container--wide {
  max-width: 1320px;
}

.signatera-eyebrow {
  display: flex;
  align-items: center;
  gap: 11px;
  margin: 0 0 12px;
  color: #e12454;
  font-size: 13px;
  font-weight: 700;
  line-height: 1.4;
  letter-spacing: 0;
  text-transform: uppercase;
}

.signatera-eyebrow::before {
  width: 32px;
  height: 2px;
  flex: 0 0 auto;
  background-color: #e12454;
  content: "";
}

.signatera-heading {
  max-width: 890px;
  margin: 0 auto 42px;
  text-align: center;
}

.signatera-heading .signatera-eyebrow {
  justify-content: center;
}

.signatera-heading h2,
.signatera-intro h2,
.signatera-proof h2,
.signatera-personalized h2,
.signatera-newsletter h2 {
  margin: 0;
  color: #073c52;
  font-size: 38px;
  font-weight: 700;
  line-height: 1.25;
}

.signatera-heading > p:last-child {
  max-width: 760px;
  margin: 16px auto 0;
  color: #54707a;
  font-size: 17px;
  line-height: 1.7;
}

.signatera-heading sup {
  color: #e12454;
  font-size: 13px;
  vertical-align: super;
}

.signatera-intro {
  padding: 88px 0;
  background-color: #fff;
}

.signatera-intro__grid {
  display: grid;
  grid-template-columns: minmax(0, 1.35fr) minmax(320px, 0.65fr);
  align-items: center;
  gap: 80px;
}

.signatera-intro__copy h2 {
  max-width: 760px;
}

.signatera-intro__copy > p:last-child {
  max-width: 780px;
  margin: 22px 0 0;
  color: #54707a;
  font-size: 17px;
  line-height: 1.8;
}

.signatera-intro__metrics {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  border-top: 4px solid #97ca3d;
  border-bottom: 1px solid #d3e3e8;
  background-color: #f2f7f9;
}

.signatera-intro__metrics div {
  min-width: 0;
  padding: 30px 22px;
  text-align: center;
}

.signatera-intro__metrics div + div {
  border-left: 1px solid #d3e3e8;
}

.signatera-intro__metrics strong,
.signatera-intro__metrics span {
  display: block;
}

.signatera-intro__metrics strong {
  color: #00658b;
  font-size: 42px;
  font-weight: 700;
  line-height: 1;
}

.signatera-intro__metrics span {
  margin-top: 10px;
  color: #54707a;
  font-size: 14px;
  font-weight: 600;
  line-height: 1.4;
}

.signatera-indications {
  padding: 82px 0 88px;
  border-top: 1px solid #dce9ed;
  background-color: #f2f7f9;
}

.signatera-indications__grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 24px;
}

.signatera-indication {
  position: relative;
  padding: 34px 30px 32px;
  border: 1px solid #d5e5ea;
  border-radius: 6px;
  background-color: #fff;
  box-shadow: 0 16px 36px rgba(7, 60, 82, 0.08);
}

.signatera-indication::before {
  position: absolute;
  top: 0;
  left: 0;
  width: 100%;
  height: 4px;
  background-color: #00a4cf;
  content: "";
}

.signatera-indication:nth-child(2)::before {
  background-color: #e12454;
}

.signatera-indication:nth-child(3)::before {
  background-color: #97ca3d;
}

.signatera-indication__icon {
  display: inline-flex;
  width: 48px;
  height: 48px;
  align-items: center;
  justify-content: center;
  border-radius: 50%;
  background-color: #e6f5f9;
  color: #00658b;
  font-size: 21px;
}

.signatera-indication h3 {
  margin: 22px 0 13px;
  color: #073c52;
  font-size: 23px;
  font-weight: 700;
  line-height: 1.3;
}

.signatera-indication p {
  margin: 0;
  color: #54707a;
  font-size: 15px;
  line-height: 1.72;
}

.signatera-indication .signatera-indication__note {
  margin-top: 20px;
  padding-top: 18px;
  border-top: 1px solid #dce8ec;
  color: #00658b;
  font-size: 14px;
  font-weight: 600;
}

.signatera-newsletter {
  padding: 64px 0;
  border-top: 4px solid #e12454;
  background-color: #073c52;
}

.signatera-newsletter__inner {
  display: grid;
  grid-template-columns: minmax(260px, 0.75fr) minmax(0, 1.25fr);
  align-items: center;
  gap: 64px;
}

.signatera-newsletter .signatera-eyebrow {
  color: #ff7799;
}

.signatera-newsletter h2 {
  color: #fff;
  font-size: 32px;
}

.signatera-newsletter__copy > p:last-child {
  margin: 15px 0 0;
  color: #c7dce3;
  font-size: 15px;
  line-height: 1.7;
}

.signatera-newsletter__form {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr)) auto;
  align-items: end;
  gap: 14px;
}

.signatera-newsletter__field label {
  display: block;
  margin-bottom: 7px;
  color: #e4f0f3;
  font-size: 13px;
  font-weight: 600;
}

.signatera-newsletter__field input {
  width: 100%;
  height: 50px;
  padding: 10px 13px;
  border: 1px solid rgba(255, 255, 255, 0.32);
  border-radius: 4px;
  outline: none;
  background-color: rgba(255, 255, 255, 0.08);
  color: #fff;
  font-size: 15px;
  transition: border-color 0.2s ease, background-color 0.2s ease;
}

.signatera-newsletter__field input:focus {
  border-color: #77d2eb;
  background-color: rgba(255, 255, 255, 0.13);
}

.signatera-newsletter__form button {
  display: inline-flex;
  min-width: 118px;
  height: 50px;
  align-items: center;
  justify-content: center;
  gap: 9px;
  padding: 10px 18px;
  border: 2px solid #e12454;
  border-radius: 4px;
  background-color: #e12454;
  color: #fff;
  font-size: 14px;
  font-weight: 700;
  cursor: pointer;
  transition: background-color 0.2s ease, border-color 0.2s ease, color 0.2s ease;
}

.signatera-newsletter__form button:hover {
  border-color: #fff;
  background-color: #fff;
  color: #073c52;
}

.signatera-newsletter__form button:disabled {
  cursor: wait;
  opacity: 0.65;
}

.signatera-newsletter__status {
  grid-column: 1 / -1;
  min-height: 20px;
  margin: 0;
  color: #fff;
  font-size: 13px;
  line-height: 1.4;
}

.signatera-newsletter__status.is-success {
  color: #b8e970;
}

.signatera-newsletter__status.is-error {
  color: #ff9bb4;
}

.signatera-ctdna,
.signatera-performance,
.signatera-process,
.signatera-faq {
  padding: 86px 0 92px;
  background-color: #fff;
}

.signatera-ctdna__points {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 20px;
  max-width: 1040px;
  margin: 0 auto 40px;
}

.signatera-ctdna__points > div {
  display: grid;
  grid-template-columns: 40px minmax(0, 1fr);
  align-items: start;
  gap: 15px;
  padding: 22px;
  border-left: 3px solid #00a4cf;
  background-color: #f1f7f9;
}

.signatera-ctdna__points i {
  display: inline-flex;
  width: 36px;
  height: 36px;
  align-items: center;
  justify-content: center;
  border-radius: 50%;
  background-color: #97ca3d;
  color: #fff;
  font-size: 14px;
}

.signatera-ctdna__points p {
  margin: 0;
  color: #36545f;
  font-size: 15px;
  line-height: 1.65;
}

.signatera-figure {
  margin: 0;
}

.signatera-figure img {
  display: block;
  width: 100%;
  height: auto;
}

.signatera-figure--soft {
  max-width: 1120px;
  margin: 0 auto;
  padding: 12px;
  border: 1px solid #d9e7eb;
  background-color: #f4f8f9;
}

.signatera-video {
  max-width: 980px;
  margin: 42px auto 0;
  overflow: hidden;
  border: 1px solid #cddfe5;
  border-radius: 6px;
  background-color: #073c52;
  box-shadow: 0 18px 42px rgba(7, 60, 82, 0.12);
}

.signatera-video wistia-player {
  display: block;
  width: 100%;
  aspect-ratio: 16 / 9;
}

.signatera-applications,
.signatera-personalized,
.signatera-coverage,
.signatera-references {
  padding: 84px 0 90px;
  border-top: 1px solid #dce9ed;
  background-color: #f2f7f9;
}

.signatera-figure--timeline,
.signatera-figure--performance,
.signatera-figure--coverage {
  padding: 18px;
  overflow-x: auto;
  border: 1px solid #d5e5ea;
  background-color: #fff;
  scrollbar-width: none;
}

.signatera-figure--timeline::-webkit-scrollbar,
.signatera-figure--performance::-webkit-scrollbar,
.signatera-figure--coverage::-webkit-scrollbar {
  display: none;
}

.signatera-proof {
  padding: 78px 0;
  background-color: #073c52;
}

.signatera-proof__grid {
  display: grid;
  grid-template-columns: minmax(0, 0.85fr) minmax(390px, 1.15fr);
  align-items: center;
  gap: 70px;
}

.signatera-proof .signatera-eyebrow {
  color: #ff7899;
}

.signatera-proof h2 {
  color: #fff;
}

.signatera-proof__copy > p:last-child {
  margin: 20px 0 0;
  color: #c7dce3;
  font-size: 17px;
  line-height: 1.75;
}

.signatera-proof__copy a {
  color: #b8e970;
  font-weight: 700;
  text-decoration: underline;
  text-underline-offset: 4px;
}

.signatera-figure--publication {
  padding: 24px;
  border: 1px solid rgba(255, 255, 255, 0.16);
  background-color: #fff;
}

.signatera-performance .signatera-heading {
  max-width: 970px;
}

.signatera-personalized__grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(420px, 0.92fr);
  align-items: center;
  gap: 68px;
}

.signatera-personalized__copy h3 {
  margin: 27px 0 13px;
  color: #00658b;
  font-size: 20px;
  font-weight: 700;
}

.signatera-personalized__copy ul {
  margin: 0;
  padding: 0;
  list-style: none;
}

.signatera-personalized__copy li {
  position: relative;
  padding-left: 28px;
  color: #54707a;
  font-size: 16px;
  line-height: 1.72;
}

.signatera-personalized__copy li + li {
  margin-top: 14px;
}

.signatera-personalized__copy li::before {
  position: absolute;
  top: 10px;
  left: 0;
  width: 10px;
  height: 10px;
  border-radius: 50%;
  background-color: #97ca3d;
  content: "";
}

.signatera-video--compact {
  width: 100%;
  margin: 0;
}

.signatera-process__steps {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 24px;
}

.signatera-process__steps article {
  position: relative;
  min-height: 330px;
  padding: 34px 30px;
  overflow: hidden;
  border: 1px solid #d5e5ea;
  border-radius: 6px;
  background-color: #fff;
  box-shadow: 0 15px 35px rgba(7, 60, 82, 0.07);
}

.signatera-process__steps article > span {
  position: absolute;
  top: 15px;
  right: 18px;
  color: #dfecef;
  font-size: 54px;
  font-weight: 700;
  line-height: 1;
}

.signatera-process__icon {
  position: relative;
  display: inline-flex;
  width: 54px;
  height: 54px;
  align-items: center;
  justify-content: center;
  border-radius: 50%;
  background-color: #e6f5f9;
  color: #00658b;
  font-size: 22px;
}

.signatera-process__steps h3 {
  position: relative;
  margin: 25px 0 13px;
  color: #073c52;
  font-size: 21px;
  font-weight: 700;
  line-height: 1.35;
}

.signatera-process__steps p {
  position: relative;
  margin: 0;
  color: #54707a;
  font-size: 15px;
  line-height: 1.7;
}

.signatera-faq {
  border-top: 1px solid #dce9ed;
}

.signatera-faq__list {
  max-width: 940px;
  margin: 0 auto;
  border-top: 1px solid #cedfe4;
}

.signatera-faq details {
  border-bottom: 1px solid #cedfe4;
}

.signatera-faq summary {
  display: flex;
  min-height: 70px;
  align-items: center;
  justify-content: space-between;
  gap: 20px;
  padding: 20px 4px;
  color: #073c52;
  font-size: 18px;
  font-weight: 700;
  line-height: 1.45;
  cursor: pointer;
  list-style: none;
}

.signatera-faq summary::-webkit-details-marker {
  display: none;
}

.signatera-faq summary i {
  flex: 0 0 auto;
  color: #e12454;
  font-size: 14px;
  transition: transform 0.2s ease;
}

.signatera-faq details[open] summary i {
  transform: rotate(45deg);
}

.signatera-faq details p {
  max-width: 840px;
  margin: -4px 0 0;
  padding: 0 48px 24px 4px;
  color: #54707a;
  font-size: 15px;
  line-height: 1.75;
}

.signatera-references {
  padding-top: 58px;
  padding-bottom: 58px;
}

.signatera-references h2 {
  margin: 0 0 20px;
  color: #073c52;
  font-size: 24px;
  font-weight: 700;
}

.signatera-references ol {
  columns: 2;
  column-gap: 52px;
  margin: 0;
  padding-left: 22px;
}

.signatera-references li {
  break-inside: avoid;
  margin-bottom: 9px;
  color: #607982;
  font-size: 12px;
  line-height: 1.55;
}

.signatera-references__disclaimer {
  margin: 28px 0 0;
  padding-top: 22px;
  border-top: 1px solid #ccdde2;
  color: #607982;
  font-size: 12px;
  line-height: 1.65;
}

@media (max-width: 1199px) {
  .signatera-intro__grid {
    gap: 50px;
  }

  .signatera-newsletter__inner {
    grid-template-columns: 1fr;
    gap: 32px;
  }

  .signatera-newsletter__copy {
    max-width: 720px;
  }

  .signatera-personalized__grid {
    gap: 44px;
  }
}

@media (max-width: 991px) {
  .signatera-heading h2,
  .signatera-intro h2,
  .signatera-proof h2,
  .signatera-personalized h2 {
    font-size: 33px;
  }

  .signatera-intro__grid,
  .signatera-proof__grid,
  .signatera-personalized__grid {
    grid-template-columns: 1fr;
  }

  .signatera-intro__metrics {
    max-width: 560px;
  }

  .signatera-indications__grid,
  .signatera-process__steps {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .signatera-indication:last-child,
  .signatera-process__steps article:last-child {
    grid-column: 1 / -1;
  }

  .signatera-proof__grid {
    gap: 38px;
  }

  .signatera-figure--publication {
    max-width: 600px;
  }

  .signatera-video--compact {
    max-width: 760px;
  }
}

@media (max-width: 767px) {
  .signatera-heading {
    margin-bottom: 30px;
  }

  .signatera-heading h2,
  .signatera-intro h2,
  .signatera-proof h2,
  .signatera-personalized h2 {
    font-size: 28px;
    line-height: 1.3;
  }

  .signatera-heading > p:last-child,
  .signatera-intro__copy > p:last-child,
  .signatera-proof__copy > p:last-child {
    font-size: 15px;
  }

  .signatera-intro,
  .signatera-indications,
  .signatera-ctdna,
  .signatera-applications,
  .signatera-proof,
  .signatera-performance,
  .signatera-personalized,
  .signatera-process,
  .signatera-coverage,
  .signatera-faq {
    padding-top: 56px;
    padding-bottom: 60px;
  }

  .signatera-intro__grid {
    gap: 34px;
  }

  .signatera-intro__metrics strong {
    font-size: 34px;
  }

  .signatera-intro__metrics div {
    padding: 24px 14px;
  }

  .signatera-indications__grid,
  .signatera-process__steps,
  .signatera-ctdna__points {
    grid-template-columns: 1fr;
  }

  .signatera-indication:last-child,
  .signatera-process__steps article:last-child {
    grid-column: auto;
  }

  .signatera-newsletter {
    padding: 48px 0;
  }

  .signatera-newsletter h2 {
    font-size: 27px;
  }

  .signatera-newsletter__form {
    grid-template-columns: 1fr;
  }

  .signatera-newsletter__form button {
    width: 100%;
  }

  .signatera-figure--soft {
    padding: 5px;
  }

  .signatera-figure--timeline,
  .signatera-figure--performance,
  .signatera-figure--coverage {
    padding: 10px;
  }

  .signatera-figure--timeline img {
    width: 920px;
    max-width: none;
  }

  .signatera-figure--performance img {
    width: 1050px;
    max-width: none;
  }

  .signatera-figure--coverage img {
    width: 940px;
    max-width: none;
  }

  .signatera-process__steps article {
    min-height: 0;
  }

  .signatera-faq summary {
    min-height: 64px;
    font-size: 16px;
  }

  .signatera-faq details p {
    padding-right: 26px;
    font-size: 14px;
  }

  .signatera-references {
    padding: 46px 0;
  }

  .signatera-references ol {
    columns: 1;
  }
}

@media (prefers-reduced-motion: reduce) {
  .signatera-page *,
  .signatera-page *::before,
  .signatera-page *::after {
    scroll-behavior: auto;
    transition-duration: 0.01ms;
  }
}